Peter Attia

"There's a whole mathematical model that we're using. It's called the Logan plot."

"We do 31P phosphor phosphorus 31 magnetic resonance spectroscopy to look at ATP production in the brain."

"We also use a modified version of an MRI to look at blood flow with ASL, arterial spin labeling, which is completely non-invasive and is also really quick."

"We can do DTI which is diffusion tensor imaging where you can see the structural connectivity of your brain all the different fibers that connect the different neurons."

"The way that this tracer works is called flurin 18 fluoroestradiol is that it goes up in the brain and it looks for the estrogen receptors."

"We use FDG like you mentioned that looks at metabolic activity in the brain."

"We also use another tracer is called C11 PIB Pittsburgh compound B which shows Alzheimer's plaques in the brain."

"What we plug on here is their VO₂ max. So this might be a 50-year-old with a VO₂ max of 40, which I think is going to place them at about the 75th percentile."

"What we're showing them is the mathematically modeled rate of decline with consistent training. If you increase your training, you can change the slope of this."

"For me, maybe we can include it in the show notes. I could show you my continuous ketone monitor, and shoots me up for I guess it's about 4 hours."

"whey protein amino acids are going to get you the same. but sometimes I don't want a milky substance and the amino acids are absorbed a little bit faster"

"really all my early work in grad school was around creatine and beta alanine and really understanding some of those impacts"

"I do like a probiotic, which is debatable, but multistrain based on my GI system"

"I kind of integrated protein shakes back and omega-3 and creatine to help maintain when you're not sitting down to eat full meals"

"we've really dialed in and looked at more of our high-intensity interval training just because it accelerates lipid and fat oxidation"

"I'm doing more stuff on a Kaiser as opposed to like jumping around and doing insane box jumps"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"whey protein amino acids are going to get you the same. but sometimes I don't want a milky substance and the amino acids are absorbed a little bit faster"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"really all my early work in grad school was around creatine and beta alanine and really understanding some of those impacts"

"I normally travel with protein snacks, I've got my David bars and my venison sticks, and I just for whatever reason I was in such a rush when I packed I didn't take any of that stuff."

"when I wanted to start reading more, I took Audible for audiobooks and moved it to the home screen on my phone"

"I'm usually 8 to nine weeks out on my column in the Atlantic because I'm trying the things that I'm suggesting."

"Shortly thereafter a CTA is done and we do indeed see soft plaque. Let's just assume you've done all of the advanced testing. You've applied the algorithms that can be layered on the CT scan."

"It's also worth pointing out a zero calcium score carries with it an approximate 15% risk of being a false negative. I've personally seen, I don't know, 10 cases of zero calcium scores that are not zero."

"I don't know if you measure your inflammatory markers like hs-CRP, mine is even non-detectable."

"What were we doing with our Abbott finger sticks? Measuring D beta hydroxybutyrate."

"I use a coffee creamer called Keto Brains. It's like alpha GPC, MCT, theanine has a couple. It's a mixture of combinations of things."

"I am very impressed with Sai Bio. So, the first week the ketone measurements are very accurate, but the last week they tend to measure about only half of what you measure in blood"

"I got the little Cardio Chek meter which was super expensive at the time. I would say 2009 I started actually checking ketones"

"I got that later. I don't even think that might have been out yet, but I got that soon after because the Cardio Chek actually did like your HDL and like triglycerides"

"Audacious Nutrition Keto Start. You're getting about 6 to 10 grams of pure beta hydroxybutyrate minus the electrolytes."

"This has been most typically and most repeatedly measured using a test called V2 max. You've heard me talk about this, of course, and it's become a very popular thing that people talk about."

"Zone 2 is the cornerstone that lets you do enough work, enough volume safely and consistently so that you get the adaptations you need to be an athlete for life."

"Belinda Beck, this woman from Australia with that Lift More study, I've always been impressed with that where they were able to basically teach these women how to do barbell deadlifts"

"starting with resistance bands at home is a starting point"

"The general strategy is easy to say but very hard to follow which is praise the good, ignore the bad. People naturally gravitate toward the things that they get rewarded for, the things they get praised for."

"You don't actually need someone to be motivated every day to do this. You really just need them to be motivated for like one afternoon so that they change the environment a bit."

"The absolute minimum thing I should use on my skin every day, it would be sunscreen."

"In addition to sunscreen and retinoids, I think that vitamin C is a really important molecule."

"In addition to sunscreen and retinoids, I think that vitamin C is a really important molecule."

"This is your vision quest is to find the answers to these by reading, by experiencing, by meditating, by spending time by yourself, by praying, by asking people's advice, by therapy. I don't know. Do your thing."

"This is your vision quest is to find the answers to these by reading, by experiencing, by meditating, by spending time by yourself, by praying, by asking people's advice, by therapy."

"We talk about blood markers like apo LP little A. I think that should be done, but you know, everybody buys themselves one of those a year."

"We're much more aggressive on PSA than what is recommended. We think it should be done annually on every male non-negotiable."

"We actually recommend low-dose CT scan for lung cancer screening. So lung cancer is the leading cause of cancer death in men and women by far."

"I think coronary imaging is pretty important especially for people who are hesitant to begin managing risk factors."

"I'm really happy to see that the guidelines for colonoscopy were moved from 50 to 45. I think that's an excellent step in the right direction. I would personally move it up one step closer to 40."

"Metabolic based therapies, ketogenic therapies, you know, diet. These things not only change metabolic physiology and brain energy metabolism but they reduce systemic inflammation."

"There's a device called Keto Air that's pretty good. It's a small, it's like the size of a pen, and that actually correlates really well with some of the blood ketone measurements"

"there's Advanced Ketogenic Therapies and it's a team of people and it's kind of spearheaded by Denise Potter. She's a registered dietitian"

"that price point has come down, but now we have the Keto-Mojo which is actually aligns more with our assays and it does the glucose ketone index that we can talk about"

"Metformin, we've done quite a bit of research with metformin and I think that's a great molecule could be a synergizer."

"You can use an SGLT2 inhibitor, you can use I mean we have about two dozen different drugs that you could use."

"Carbon app is great. I know you've had Layne on. I've used that"

"And by the way, even if I was going to replace it, I would not be using testosterone. I'd be using hCG."

"But if you actually go through even something as rudimentary as the CDC mortality tables and slice them by 5-year increments you can't explain the increased prevalence by a factor of 2 to one on that delta in age."

"I look at the potential around GLP-1 agonist and I look at the ways that we're getting better understanding of hormones"

"This specific substance leaves your reproductive organs alone but goes up into the brain and binds to the estrogen receptor better with high affinity, therefore stimulating cognition in terms of memory for instance or executive function."

"We could look at C2N, we could look at PAL, we could look at any of the other brain metabolomics, we could look at so many things."

"What do you think of the commercially available versions of PTA and these other studies?"

"Studies like care and other prospective cohort studies and large-scale bio repositories I think they're so important like the UK bio bank thousands and thousands and thousands of blood samples that can be used and analyzed for these purposes."

"For those interested in Alzheimer's disease, whenever it comes to Alzheimer's prevention, we look at the recommendations of the Lancet Commission, which every few years produce an update."

"I have seen some unpublished data that suggest that very low like 2.5 milligrams of tirzepatide as an example is meaningfully reducing blood-based and CSF-based markers of neuroinflammation and protein aggregation."

"I just launched a $50 million program of research sponsored by Welcome Leap, which is an independent subsidiary of the Welcome Trust."

"I just launched a $50 million program of research sponsored by Welcome Leap, which is an independent subsidiary of the Welcome Trust."

"for me to get a bottle of corn oil or any of the other seed oils on your table, I have to do a lot of industrial processing"

"I'm not going to be able to get all the hexane off this molecule, and I needed to use hexane to extract it, right?"

"Can you go into a grocery store and choose to have safflower oil that was mechanically extracted versus chemically extracted?"

"I think I read like soybean oil, if you heat it at like 240 degrees Celsius for like 3 hours, you will start to get like a percent of the oil being oxidized"

"Why care about nutrition if you can just control this with statins?"

"would we be better off when it comes to heating oil using lard? In other words, if I'm going to have French fries, should I at least have my French fries made in lard as opposed to polyunsaturated fat and seed oil?"

"This is a study that took place in the 1960s. I believe it ran 7 years. It's notable because it was carried out in an environment that would be very difficult to do today."

"If, for example, when you're making a salad, you prefer the taste of safflower oil or canola oil over olive oil. Doesn't seem like you're killing yourself by doing it based on the data."

"The Sydney heart study, which is the one you're referring to, attempts to solve this. So, it was a much smaller study than the Minnesota coronary experiment, which had nearly 9,000 subjects."

"of the two hours that you're going to be left for say running on a treadmill or being on an exercise bike"

"of the two hours that you're going to be left for say running on a treadmill or being on an exercise bike"

"The nice thing is on a bike or on a treadmill, if you're doing it on some sort of ergometer, the power or the speed are locked in and that forces you into the effort."

"Do you see any other mom killing you on the flag football or the baseball? It allows me to be out there and to keep up with them as well."

"Do you see any other mom killing you on the flag football or the baseball? It allows me to be out there and to keep up with them as well."

"We did muscle quality from ultrasound and PQCT. And that PQCT is very related to MRI"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"or is she excited to go do Silver Sneakers somewhere?"

"we just finished a project looking at microdialysis. So this was within the fat. It can also be done within the muscle"

"we're measuring that with different ways not with biopsy but both with indirect calorimetry through metabolic flexibility"

"We did muscle quality from ultrasound and PQCT"

"We have some of that data now that we've looked at with MRI and it's the same theme"

"If I'm sitting here drinking six Mountain Dews a day, would I be better off doing everything the same but moving to six diet Mountain Dews a day?"

"We talked last time we talked we were talking about From Strength to Strength which was my last book."

"One of the people who works in my area, Dacher Keltner at UC Berkeley, he has a book called Awe, that talks about the neurocognitive processes involved when you're experiencing awe and why it gives you such deep peace."

"You can also find me on YouTube, Instagram, and Twitter, all with the handle Peter MD."

"Aquinas in 1265 writes the Summa Theologica, magisterial contribution to philosophy."

"You can also leave us review on Apple Podcasts or whatever podcast player you use."

"It's also worth pointing out a zero calcium score carries with it an approximate 15% risk of being a false negative."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"Advised a little bit for RX Sugar, which sold alulose."

"We're working with NAD compounds MIB 626 and other compounds. I can't talk about that because it's through an industry."

"There was the Biosense device, but they've kind of fallen out of favor"

"electrolytes similar blend as Element but bound to beta hydroxybutyrate"

"I'm an adviser for Levels Health."

"I'm an adviser for MedSAI, METYS. It's essentially an app and a program for metabolic psychiatry."

"Can you do the CAG repeat? I mean, I guess you could. That would be... someone should develop a CLIA approved assay for this."

"I would love to have an assay to measure androgen receptor density. We don't have a test for it."

"It was in the New England Journal of Medicine. I don't remember who published this."

"There were a lot of doctors out there who were prescribing aromatase inhibitors to keep estrogen as low as possible in men."

"I went down the rabbit hole on this a year ago of looking at every single one of the wrist-based heart rate monitors and I was blown away at how inaccurate wrist-based heart rate monitors were."

"If I'm sitting here drinking six Mountain Dews a day, would I be better off doing everything the same but moving to six diet Mountain Dews a day?"