Peter Attia

"What we plug on here is their VO₂ max. So this might be a 50-year-old with a VO₂ max of 40, which I think is going to place them at about the 75th percentile."

"What we're showing them is the mathematically modeled rate of decline with consistent training. If you increase your training, you can change the slope of this."

"For our patients, we actually do the test. We got sort of tired of relying on other labs to do it."

"whey protein amino acids are going to get you the same. but sometimes I don't want a milky substance and the amino acids are absorbed a little bit faster"

"whey protein amino acids are going to get you the same. but sometimes I don't want a milky substance and the amino acids are absorbed a little bit faster"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"I do like a probiotic, which is debatable, but multistrain based on my GI system"

"I kind of integrated protein shakes back and omega-3 and creatine to help maintain when you're not sitting down to eat full meals"

"really all my early work in grad school was around creatine and beta alanine and really understanding some of those impacts"

"really all my early work in grad school was around creatine and beta alanine and really understanding some of those impacts"

"I normally travel with protein snacks, I've got my David bars and my venison sticks, and I just for whatever reason I was in such a rush when I packed I didn't take any of that stuff."

"we've really dialed in and looked at more of our high-intensity interval training just because it accelerates lipid and fat oxidation"

"I'm doing more stuff on a Kaiser as opposed to like jumping around and doing insane box jumps"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"omega-3, vitamin D, magnesium, creatine, multivitamin, those are the key ones"

"when I wanted to start reading more, I took Audible for audiobooks and moved it to the home screen on my phone"

"It's also worth pointing out a zero calcium score carries with it an approximate 15% risk of being a false negative. I've personally seen, I don't know, 10 cases of zero calcium scores that are not zero."

"Shortly thereafter a CTA is done and we do indeed see soft plaque. Let's just assume you've done all of the advanced testing. You've applied the algorithms that can be layered on the CT scan."

"I don't know if you measure your inflammatory markers like hs-CRP, mine is even non-detectable."

"For me, maybe we can include it in the show notes. I could show you my continuous ketone monitor, and shoots me up for I guess it's about 4 hours."

"What were we doing with our Abbott finger sticks? Measuring D beta hydroxybutyrate."

"Audacious Nutrition Keto Start. You're getting about 6 to 10 grams of pure beta hydroxybutyrate minus the electrolytes."

"I use a coffee creamer called Keto Brains. It's like alpha GPC, MCT, theanine has a couple. It's a mixture of combinations of things."

"This has been most typically and most repeatedly measured using a test called V2 max. You've heard me talk about this, of course, and it's become a very popular thing that people talk about."

"Zone 2 is the cornerstone that lets you do enough work, enough volume safely and consistently so that you get the adaptations you need to be an athlete for life."

"Belinda Beck, this woman from Australia with that Lift More study, I've always been impressed with that where they were able to basically teach these women how to do barbell deadlifts"

"starting with resistance bands at home is a starting point"

"The general strategy is easy to say but very hard to follow which is praise the good, ignore the bad. People naturally gravitate toward the things that they get rewarded for, the things they get praised for."

"You don't actually need someone to be motivated every day to do this. You really just need them to be motivated for like one afternoon so that they change the environment a bit."

"In addition to sunscreen and retinoids, I think that vitamin C is a really important molecule."

"The absolute minimum thing I should use on my skin every day, it would be sunscreen."

"In addition to sunscreen and retinoids, I think that vitamin C is a really important molecule."

"This is your vision quest is to find the answers to these by reading, by experiencing, by meditating, by spending time by yourself, by praying, by asking people's advice, by therapy."

"This is your vision quest is to find the answers to these by reading, by experiencing, by meditating, by spending time by yourself, by praying, by asking people's advice, by therapy. I don't know. Do your thing."

"We're much more aggressive on PSA than what is recommended. We think it should be done annually on every male non-negotiable."

"I'm really happy to see that the guidelines for colonoscopy were moved from 50 to 45. I think that's an excellent step in the right direction. I would personally move it up one step closer to 40."

"I think coronary imaging is pretty important especially for people who are hesitant to begin managing risk factors."

"We talk about blood markers like apo LP little A. I think that should be done, but you know, everybody buys themselves one of those a year."

"We actually recommend low-dose CT scan for lung cancer screening. So lung cancer is the leading cause of cancer death in men and women by far."

"Metabolic based therapies, ketogenic therapies, you know, diet. These things not only change metabolic physiology and brain energy metabolism but they reduce systemic inflammation."

"Metformin, we've done quite a bit of research with metformin and I think that's a great molecule could be a synergizer."

"You can use an SGLT2 inhibitor, you can use I mean we have about two dozen different drugs that you could use."

"And by the way, even if I was going to replace it, I would not be using testosterone. I'd be using hCG."

"But if you actually go through even something as rudimentary as the CDC mortality tables and slice them by 5-year increments you can't explain the increased prevalence by a factor of 2 to one on that delta in age."

"I look at the potential around GLP-1 agonist and I look at the ways that we're getting better understanding of hormones"

"I have seen some unpublished data that suggest that very low like 2.5 milligrams of tirzepatide as an example is meaningfully reducing blood-based and CSF-based markers of neuroinflammation and protein aggregation."

"We could look at C2N, we could look at PAL, we could look at any of the other brain metabolomics, we could look at so many things."

"What do you think of the commercially available versions of PTA and these other studies?"

"Can you go into a grocery store and choose to have safflower oil that was mechanically extracted versus chemically extracted?"

"I'm not going to be able to get all the hexane off this molecule, and I needed to use hexane to extract it, right?"

"for me to get a bottle of corn oil or any of the other seed oils on your table, I have to do a lot of industrial processing"

"I think I read like soybean oil, if you heat it at like 240 degrees Celsius for like 3 hours, you will start to get like a percent of the oil being oxidized"

"would we be better off when it comes to heating oil using lard? In other words, if I'm going to have French fries, should I at least have my French fries made in lard as opposed to polyunsaturated fat and seed oil?"

"Why care about nutrition if you can just control this with statins?"

"This is a study that took place in the 1960s. I believe it ran 7 years. It's notable because it was carried out in an environment that would be very difficult to do today."

"would we be better off when it comes to heating oil using lard? In other words, if I'm going to have French fries, should I at least have my French fries made in lard as opposed to polyunsaturated fat and seed oil?"

"If, for example, when you're making a salad, you prefer the taste of safflower oil or canola oil over olive oil. Doesn't seem like you're killing yourself by doing it based on the data."

"Can you go into a grocery store and choose to have, you know, safflower oil that was mechanically extracted versus chemically extracted?"

"The Sydney heart study, which is the one you're referring to, attempts to solve this. So, it was a much smaller study than the Minnesota coronary experiment, which had nearly 9,000 subjects."

"for me to get a bottle of corn oil or any of the other seed oils on your table, I have to do a lot of industrial processing."

"If you were measuring lactate in the bloodstream with a continuous lactate monitor, which by the way, these things are easily in prototype and there's some that are right on the market."

"of the two hours that you're going to be left for say running on a treadmill or being on an exercise bike"

"of the two hours that you're going to be left for say running on a treadmill or being on an exercise bike"

"That's going to be my endurance training. How much of that 3 hours are you going to want to put in the weight room versus on the treadmill?"

"The nice thing is on a bike or on a treadmill, if you're doing it on some sort of ergometer, the power or the speed are locked in and that forces you into the effort."

"Do you see any other mom killing you on the flag football or the baseball? It allows me to be out there and to keep up with them as well."

"Do you see any other mom killing you on the flag football or the baseball? It allows me to be out there and to keep up with them as well."

"we're measuring that with different ways not with biopsy but both with indirect calorimetry through metabolic flexibility"

"We did muscle quality from ultrasound and PQCT. And that PQCT is very related to MRI"

"we just finished a project looking at microdialysis. So this was within the fat. It can also be done within the muscle"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"We have some of that data now that we've looked at with MRI and it's the same theme"

"We did muscle quality from ultrasound and PQCT"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"how do we combine our GLP-1s with the kind of what I would call a minimal effective dose of exercise and nutrition"

"or is she excited to go do Silver Sneakers somewhere?"

"So is it DEXA, is it bodpod, is it bioelectrical impedance? and knowing that those numbers are all very different"

"If I'm sitting here drinking six Mountain Dews a day, would I be better off doing everything the same but moving to six diet Mountain Dews a day?"

"We talked last time we talked we were talking about From Strength to Strength which was my last book."

"One of the people who works in my area, Dacher Keltner at UC Berkeley, he has a book called Awe, that talks about the neurocognitive processes involved when you're experiencing awe and why it gives you such deep peace."

"You can also find me on YouTube, Instagram, and Twitter, all with the handle Peter MD."

"You can also leave us review on Apple Podcasts or whatever podcast player you use."

"It's also worth pointing out a zero calcium score carries with it an approximate 15% risk of being a false negative."

"Let's just assume that you've done all of the advanced testing. You know, you've applied the algorithms that can be layered on the CT scan and you're really really confident this person has pristine coronary arteries."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"I could sit down with a bag of macadamia nuts and polish the bag off or sour cream or heavy cream or whatever."

"I'm an adviser for Levels Health."

"Advised a little bit for RX Sugar, which sold alulose."

"I'm an adviser for MedSAI, METYS. It's essentially an app and a program for metabolic psychiatry."

"We're working with NAD compounds MIB 626 and other compounds. I can't talk about that because it's through an industry."

"I would love to have an assay to measure androgen receptor density. We don't have a test for it."

"Can you do the CAG repeat? I mean, I guess you could. That would be... someone should develop a CLIA approved assay for this."

"If I could wave a magic wand in medicine right now, I would have a PSA equivalent for breast cancer."

"I would love to have an assay to measure androgen receptor density."

"It was in the New England Journal of Medicine. I don't remember who published this."

"There were a lot of doctors out there who were prescribing aromatase inhibitors to keep estrogen as low as possible in men."

"I went down the rabbit hole on this a year ago of looking at every single one of the wrist-based heart rate monitors and I was blown away at how inaccurate wrist-based heart rate monitors were."

"If I'm sitting here drinking six Mountain Dews a day, would I be better off doing everything the same but moving to six diet Mountain Dews a day?"

"when I look at treatments like Clotho and just full disclosure I'm a co-founder of a company that is trying to develop a Clotho injection"

"Hey everyone, welcome to the Drive podcast. I'm your host, Peter Attia."

"this is one of the stories I share in Atomic Habits, but it was this surprise that we saw from the Vietnam War"

"We call those the centenarian decathlon goals. We've developed a tool to actually take the exercise of thinking about that and having that discussion from an abstract discussion into a very tangible discussion."

"I devoted an entire chapter of Outlive I think chapter 4 is dedicated to making this point which is you could take two strategies to approach lifespan elongation."