David Sinclair
58 things David uses or recommends, from 11 episodes.
David's top picks
What David uses or recommends most, ranked by how often and how strongly. Paid ads are left out.
NMN
+3 other experts
Uses and recommends it · talked about in 7 episodes
"I take one gram of NMN every morning along with my resveratrol. The reason is in humans we know that that doubles NAD levels, which is important because someone my age has half the levels of NAD than I did when I was 20... And I do find anecdotally that NMN is remarkably good at preventing jet lag as well."
Resveratrol
+2 other experts
Uses and recommends it · talked about in 8 episodes
"Resveratrol — it's been back and forth controversial. It's not controversial in scientific circles. I've been taking about a teaspoon, call it a gram of resveratrol every morning, almost every morning for the last probably 20 years. Doing all right. It seems to help in clinical trials. I mix it with either a little bit of olive oil or Greek yogurt or vegan yogurt."
Metformin
+3 other experts
Uses and recommends it · talked about in 6 episodes
"I had terrible blood biochemistry. I was eating badly, I gained weight. I wasn't sleeping. I was stressed... So I went on NMN and things were somewhat rectified. And then I added Metformin and they really got back to my optimal."
Continuous glucose monitors
+10 other experts
Uses and recommends it · talked about in 4 episodes
"Love them. They're really good. I think we should all be empowered by our own data. The CGMs have been very useful. Personally, I can see how I react to foods — grapes send me through the roof, white rice through the roof. I'm wearing one right now. I wear them fairly regularly. I gave one to my son who at the time was 17 and it changed his life — he's eating much healthier."
Nattokinase
+1 other expert
Uses and recommends it · talked about in 3 episodes
"A new one that we've added in the last couple of years is nattokinase. Really the only thing that's been very clearly shown in large trials of thousand plus people to reverse plaque in the body. You need at least 10,000 units and it took a year, so you need to be consistent."
Plant-based diet
Health & fitness
Uses and recommends it · talked about in 3 episodes
"What I didn't realize till I was in my 50s was how important food is. I thought vegetables were a garnish for meat. I love meat — it tastes great. But I've switched over to being more plant-focused and I've seen a great improvement in my overall health and biomarkers."
What David warns against
Things David says to avoid or be careful with. Other experts don't always agree.
Multivitamin
"I'm not for multivitamins. Overall, taking a lot of multivitamins is excessive and it can actually be toxic if you have too much. Vitamin C can be pro-oxidant rather than antioxidant if you take a lot continuously."
Mark Hyman, MD, Abbie Smith-Ryan and 5 others
recommend it
B Vitamins
"The overdosing of vitamins, particularly B vitamins — I nibble on my B vitamins, I don't take the whole thing. Overdosing on vitamins, especially B, can be one of the biggest wastes of money. IV B vitamins? You'll get a short-term hit, but I don't recommend overdosing."
Stasha Gominak and Tommy Wood
recommend it
Mouth tape
"I have tried mouth taping and Serena says I make even more noises gasping. So I don't use mouth tape. I haven't had success myself with mouth taping."
Andy Stumpf and James Nestor
recommend it
Experts most like David Sinclair
They use many of the same things David does. Pick the ones you trust and see what they all swear by.
All 58 of David's picks
- NMN Uses and recommends it 7 episodes "I take one gram of NMN every morning along with my resveratrol. The reason is in humans we know that that doubles NAD levels, which is important because someone my age has half the levels of NAD than I did when I was 20... And I do find anecdotally that NMN is remarkably good at preventing jet lag as well." +3 others
- Resveratrol Uses and recommends it 8 episodes "Resveratrol — it's been back and forth controversial. It's not controversial in scientific circles. I've been taking about a teaspoon, call it a gram of resveratrol every morning, almost every morning for the last probably 20 years. Doing all right. It seems to help in clinical trials. I mix it with either a little bit of olive oil or Greek yogurt or vegan yogurt." +2 others
- Metformin Uses and recommends it 6 episodes "I had terrible blood biochemistry. I was eating badly, I gained weight. I wasn't sleeping. I was stressed... So I went on NMN and things were somewhat rectified. And then I added Metformin and they really got back to my optimal." +3 others
- Continuous glucose monitors Uses and recommends it 4 episodes "Love them. They're really good. I think we should all be empowered by our own data. The CGMs have been very useful. Personally, I can see how I react to foods — grapes send me through the roof, white rice through the roof. I'm wearing one right now. I wear them fairly regularly. I gave one to my son who at the time was 17 and it changed his life — he's eating much healthier." +10 others
- Nattokinase Uses and recommends it 3 episodes "A new one that we've added in the last couple of years is nattokinase. Really the only thing that's been very clearly shown in large trials of thousand plus people to reverse plaque in the body. You need at least 10,000 units and it took a year, so you need to be consistent." +1 other
- Plant-based diet Uses and recommends it 3 episodes "What I didn't realize till I was in my 50s was how important food is. I thought vegetables were a garnish for meat. I love meat — it tastes great. But I've switched over to being more plant-focused and I've seen a great improvement in my overall health and biomarkers." Only David
- Fasting Uses and recommends it 2 episodes "3 days fasting is good. A week can be even better. I couldn't do it — I tried a GLP-1 receptor agonist and it was easy. Now I can fast for two weeks. I now know that I can do it mentally — it's not hard at all. You go into what's called deep cleansing — chaperone-mediated autophagy or CMA — and it cleans out a lot of the old proteins in your body. Ketosis doesn't just make you feel good; you're actually renewing your protein in your body and rebuilding it." +2 others
- GLP-1 Uses and recommends it 2 episodes "In general, I'm very favorable. If you're obese, it's almost a must — go talk to your doctor. I think if you can't lose weight alone, please consider using these. I think obesity is the fastest way to an early grave. It's as close to a longevity drug as we probably have right now. I have taken GLP-1s at small doses to see how I would feel. I definitely didn't have hunger and I lost weight more easily." +9 others
- One Meal a Day (OMAD) Uses and recommends it 2 episodes "Generally I like to eat one meal a day, maybe two if I'm being social but not three. I think three meals a day plus snacks is marketing." Only David
- Oura Ring Uses and recommends it 2 episodes "This is an Oura, the fat one. I find Oura really good for sleep — that's their specialty. They're getting even better because they now pop up with AI information. They're becoming like a personal health advisor. I can see sleep efficiency above 90 sometimes." +12 others
- Red light cap Uses and recommends it 2 episodes "I use a red light cap on my head to preserve my hairline... I do this red light cap when I can... for 6 minutes. Proven. It's proven to slow hair loss." Only David
- Berberine Uses and recommends it 3 episodes "I change from metformin to this other more natural or totally natural form called berberine. Berberine has been shown clinically to reduce blood glucose very similar to what metformin does." +2 others
- Niacin Uses and recommends it 2 episodes "I'm taking high-dose vitamin B3 or niacin... I'm taking half a gram. Some people take a gram. And that's one of the few things that's been known to bring down the levels of LP little A." Only David
- Statins Uses and recommends it 3 episodes "I've been taking statins since I was 29... So I've now got my cholesterol down to low, low levels... I'm willing to forgo the risk that the statin is causing problems later because of my family history. But other people, I would say, be aware that statins aren't perfect drugs." +2 others
- InsideTracker Uses and recommends it 2 episodes "I've been doing blood tests for the last 12 years with a company called InsideTracker, which I consult for, and so I have all of that data as well, and there's 34 different parameters on my testosterone, my blood glucose, my inflammation, and I use all that data to keep my body in optimal shape... You can definitely use it. You can sign up, it's consumer." Only David
- Intermittent Fasting Uses and recommends it 2 episodes "If you can go skip breakfast, have a late lunch, that's a good start. That's what I try to do every day... these genes that extend lifespan, these sirtuin genes, are activated by being hungry, in part by raising NAD levels." +9 others
- Aspirin Uses and recommends it 2 episodes "I take a baby aspirin every day... Someone like me, I believe it makes perfect sense to take aspirin every day." Only David
- Blue Light Blocking Glasses Uses and recommends it 2 episodes "Blue light blocking glasses — I prefer to turn down the brightness of the lights at night and have a TV that's not so bright. But yes, I think they were much more fashionable 5 years ago, but I still use them." +1 other
- Withings Scale Uses and recommends it 2 episodes "I do like the Withings scale because I've had one since 2013, so I've got all this data on my body weight and composition, which is awesome. And I'm trying to maintain that at the optimal level over these last 13 years." Only David
- Spermidine Uses and recommends it 2 episodes "The reason that I take it is that it extends the lifespan of every animal that it's been given to from worms to mice. And it's a very safe molecule." Only David
- Tadalafil Uses and recommends it "I take Cialis — tadalafil — every morning, a low dose. I do that because in 2012 we published a paper that showed that one of the most pernicious causes of aging is low blood flow, and we could reverse that with NMN through SIRT1 — more blood flow. I take this low dose in the hopes and expectation that if I get dementia it will be a decade later. And now add on that cancer killing. It's an amazing drug." +2 others
- Glycine Uses and recommends it "I take about 5 grams of glycine most days... it's very safe and again falls into the same category as spermidine. No downside." +1 other
- Ketone IQ Uses and recommends it "I drink Ketone IQ before I do a podcast. It improves my clarity... I get the clarity of fasting without being in a fasted state." +1 other
- Matcha Uses and recommends it "The reason for switching from coffee mainly to matcha in the morning for me is that it's full of polyphenols... I highly recommend it." +1 other
- Stevia Uses it 2 episodes "Stevia, I do use Stevia whenever I can, because it's a naturally sourced product. And I haven't seen any good evidence yet that it's bad for you." Only David
- Homemade Yogurt Uses and recommends it "I got addicted to the yogurt and so is everyone in my family now... it's really easy. You get packets, there's three different packets, you rip them open, put them in whole milk, shake it and stick it in the oven on defrost for 24 hours." Only David
- Creatine monohydrate Uses and recommends it "Creatine — in favor of it, and I take it." +26 others
- Hyperbaric oxygen Uses and recommends it "Hyperbaric oxygen therapy — in favor. There's good evidence that cycling up and down in pressure is good for the brain and blood flow. I have done it myself and have seen improvements in wound healing in others. So yeah, in general it's a plus." +4 others
- Ketosis Uses and recommends it "Ketosis is one. You go into what's called deep cleansing — chaperone-mediated autophagy or CMA. Ketosis doesn't just make you feel good; you're actually renewing your protein in your body and rebuilding it. I do that as an anti-aging thing." +1 other
- AI-driven drug design Uses and recommends it "We are working with companies and academics that do a lot of AI now. It's accelerating our work exponentially. AI-driven drug design and looking at billions and eventually trillions of molecules to see which ones might reverse aging. We've done that already." Only David
- AST/ALT liver test Uses and recommends it "You don't know if you're doing good or harm to your body unless you measure it, particularly your liver. You can measure what's called AST/ALT. I do that routinely just to make sure nothing's going wrong in that regard." Only David
- Olive oil Uses and recommends it "I've realized that olive oil and particularly oleic acid, one of the monounsaturated fatty acids, is also an activator of the sirtuin defenses. So I'm trying to ingest more oleic acid. So I switched to olive oil." +5 others
- BioButton Uses and recommends it "I'm currently wearing a little what's called a bio sticker... It immediately syncs to your phone, and this one, it's called a BioButton, a nice name... It's already told me this morning how I slept, where I slept, what side I slept on." Only David
- Homemade Whole Milk Yogurt Uses and recommends it "I got so hooked on this type of yogurt... I got addicted to the yogurt and so is everyone in my family now... You get packets, there's three different packets, you rip them open, put them in whole milk, shake it and stick it in the oven on defrost for 24 hours." Only David
- Sauna and Cold Plunge Uses and recommends it "This season I went to the sauna and the cold shock bath and that really helped a lot. I don't know if it's related, but I needed to shock my body in the middle of winter." Only David
- Alpha Lipoic Acid Uses it "I still like alpha lipoic acid for mitochondrial health. So I've been taking that for over a decade now. I did a PhD on it, so I know a little bit about its benefits." +3 others
- CoQ10 Uses it "CoQ10, of course, because I'm actually on a statin." +2 others
- Near Infrared Light Panel Uses it "The red light is not crazy. Certain infrared — I've got near infrared panels. I have that actually. I shine that in the shower sometimes. The science is coming around to confirming some benefits there. I think that's fine." Only David
- Nose Strips Uses it "I do use those nose strips because Serena thinks they help." Only David
- Extended Fasting Uses it "I'll come home from travel and just I won't eat for 3 days. Sometimes 2 weeks I can go without food. It's not a big deal for me. After those 3 days, I start to feel amazing. My mind clears. I don't feel bloated at all. I feel energized." +1 other
- Vitamin B Uses it "I'm making sure that I'm not deficient in any minerals or vitamins, and so I'm taking in things like vitamin B, vitamin C as well, and some nutrients that I know I can become deficient in." Only David
- Vitamin C Uses it "I'm making sure that I'm not deficient in any minerals or vitamins, and so I'm taking in things like vitamin B, vitamin C as well, and some nutrients that I know I can become deficient in." +7 others
- AlphaFold Uses it "We dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind — solved the problem of how do all our proteins look, 20,000 of them." +2 others
- Armodafinil Uses it "Armodafinil for talks when I'm traveling. It gets rid of my jet lag and I can focus. If I'm on it, I'm on point every time." Only David
- Ultrahuman Ring Uses it "The thinner one is called Ultrahuman. The heart — for Ultrahuman, my cardiac age. I don't get paid by these companies, but I do like that they pop up with AI information now." Only David
- Extra virgin olive oil Uses it "I do take a teaspoon of olive oil in the morning and mix it with resveratrol polyphenol." +2 others
- Vitamin D Uses it "I take a vitamin D supplement. Serena actually I take Serena's supplement because her vitamin D has vitamin K2 as well." +18 others
- Quercetin Uses it "There are clinical trials being run out of the Mayo Clinic for fisetin and for quercetin. These are high doses... Myself, I'm on a maintenance dose. I take about half a gram of each every day." +2 others
- High-sensitivity CRP test Recommends it "There's a high-sensitivity CRP, your doctor will know. Get one of those readings. 'Cause if you've got normal blood sugar levels, your doctor might say you're fine. But a lot of people have normal blood sugar, but have high CRP, which is just as bad for you long-term, and can predict a future heart attack." Only David
- TSA PreCheck Uses it "If you want to pay for the TSA Pre in America, that's the way to get around those scanners, you can do that. So I travel a lot, so it's worth it anyway, but I just go through the metal detector, I don't get scanned." Only David
- hs-CRP test Recommends it "There's a high-sensitivity hs-CRP, your doctor will know. Get one of those readings. 'Cause if you've got normal blood sugar levels, your doctor might say you're fine. But a lot of people have normal blood sugar, but have high CRP, which is just as bad for you long-term, and can predict a future heart attack." +1 other
- Apple Watch Uses it "What's useful with it is pulse and activity, and if I haven't moved enough during the day... just on my phone have a look." +7 others
- Sauna and Cold Tub Uses it "I lift weights for an hour, then do a fair bit of stretching, and then actually do some hot and cold treatment... I don't have a cryo handy at my place, but I do the sauna and then cold tub." Only David
- Standing Desk Uses it "I've got a standing desk and that's been helpful to make me move around a little bit more." Only David
- Whole Milk Uses it "I use whole milk in my day. It's surprising, right, because I'm trying to avoid calories, but the benefits in taste and how I feel..." Only David
- Sauna Recommends it "Definitely sauna — there's a lot of evidence, mostly Nordic men have been studied. If you do regular sauna bathing in Finland a few times a week, your rate of heart disease can be much less, and that is reproducible. I think saunas are great. I try to do some of that myself, as hot as I can bear. I would probably take a sauna 20 times over taking a cold plunge if I'm going to try and do something for my health." +20 others
- National Geographic Recommends it "I subscribe to National Geographic for my kids. I think get them used to reading because it's going to be a lost art if we don't." Only David
- PubMed Central Recommends it "You can go to what's called PubMed Central and find papers. People are educating themselves just like scientists used to." Only David