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Fasting

technique
Andrew Huberman David Sinclair
+1

3 creators use or recommend it

▲ 2 active in the last 90 days

3 use 1 mention
Last discussed Sep 28, 2026

A dietary technique involving periods without food intake that can have positive effects on cellular health and the epigenome.

What else do they all swear by?

Andrew Huberman and David Sinclair use or recommend Fasting. See what else they have in common.

See what they all swear by Or pick your own people

What creators think

David Sinclair is the strongest advocate here, saying he now fasts for up to two weeks at a stretch and crediting extended fasting with triggering autophagy — specifically what he calls chaperone-mediated autophagy — which he claims clears out old proteins and supports longevity and cognitive function; those are his claims, not established fact. Adam Neumann, Andrew Huberman, and David Friedberg each mention fasting in passing — Huberman tried it on long-haul flights on someone else's suggestion and was surprised it helped with time-zone adjustment, while noting it could be placebo; Neumann describes the mental clarity he's personally noticed; Friedberg says simply that fasting "does have an effect." None of those three are putting their weight behind it as a recommendation.

How Fasting compares

1 creator weighed in
G
GLP-1 Different focus
weight loss injection drugs

David used GLP-1 as a stepping stone to make fasting easier, then fasted two weeks. Fasting drives deep cellular cleanup GLP-1 alone doesn't.

1 creator
David Sinclair

"3 days fasting is good. A week can be even better. I couldn't do it — I tried a GLP-1 receptor agonist and it was easy. Now I can fast for two weeks. I now know that I can do it mentally — it's not hard at all. You go into what's called ..."

GLP-1s used as a training tool to make fasting easier for those who struggle

What creators say

AN
Used for: Achieving mental clarity through voluntary food abstention Praised: Produces significant mental clarity after 12–24 hours vs: Used as analogy to Technology Shabbat — both involve short-term discomfort fo...

"Have you ever fasted? Does your brain get very clear? Have you noticed when fasting, after 12 hours, 18 hours, 24 — depending — how clear your head becomes? Your body doesn't want it, but you've tested it and you know that you get clarity from it."

More from Adam Neumann →
Used for: Triggering adversity mode, activating SIRT1, promoting chaperone-mediated autophagy (CMA), improving metabolic health and longevity Praised: Activates SIRT1 and CMA (deep cellular cleanse after 3 days); clears mind; re... vs: Three meals a day plus snacks described as 'marketing'; breakfast as most imp...

"I like to eat one meal a day, maybe two if I'm being social, but not three. I think three meals a day plus snacks is marketing. I'll come home from travel and just won't eat for three days. Sometimes two weeks I can go without food. After the firs..."

More from David Sinclair →
+1 more mention from David

"3 days fasting is good. A week can be even better. I couldn't do it — I tried a GLP-1 receptor agonist and it was easy. Now I can fast for two week..."

Used for: Shifting circadian clocks during long-haul flights to reduce jet lag Praised: May help shift peripheral clocks (liver, gut); meal timing is a robust arousa...

"She gave me a tip and I tried it — could be a placebo, who knows? She said just fast on the long flights. I tried that going to Asia. I was totally fine. I couldn't believe it. Fasting may allow for shifting those peripheral clocks."

More from Andrew Huberman →
DF
David Friedberg
mentioned

"Well, fasting helps. Fasting does have an effect"

More from David Friedberg →

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