Explore autophagy

Changing relationship to hunger, overall health improvement, extended fasting windows of 17-18 hours

"Skipping breakfast is amazing. I encourage you guys to do it very frequently. To give you an idea, I haven't eaten since yesterday at 2 p.m. and it's now 8:15 a.m. So by the time I eat, I'll have gone 17-18 hours without eating. Intermittent fasting will ch..."

Tom Bilyeu

Weight loss — used in combination with GLP-1 medications to go from 213 to 168 lbs.

"I start doing intermittent fasting. Boom. I was just able to go from 213 to 168, you know, just very elegantly."

This Week in Startups

Triggering adversity mode, activating SIRT1, promoting chaperone-mediated autophagy (CMA), improving metabolic health and longevity

"I like to eat one meal a day, maybe two if I'm being social, but not three. I think three meals a day plus snacks is marketing. I'll come home from travel and just won't eat for three days. Sometimes two weeks I can go without food. After the first three da..."

David Sinclair

Anti-aging, cellular renewal via autophagy, protein renewal, longevity

"3 days fasting is good. A week can be even better. I couldn't do it — I tried a GLP-1 receptor agonist and it was easy. Now I can fast for two weeks. I now know that I can do it mentally — it's not hard at all. You go into what's called deep cleansing — cha..."

David Sinclair

Resetting body weight after travel, triggering chaperone-mediated autophagy (CMA), clearing misfolded proteins

"I'll come home from travel and just I won't eat for 3 days. Sometimes 2 weeks I can go without food. It's not a big deal for me. After those 3 days, I start to feel amazing. My mind clears. I don't feel bloated at all. I feel energized."

David Sinclair

Morning longevity protocol, about a gram per day

"There's a company that makes it in pure from very low levels of gluten. And just the last few months I've added that to my protocol and we'll have to see how my numbers look on InsideTracker."

David Sinclair