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ketamine

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A dissociative anesthetic drug that has FDA approval for treatment-resistant depression but has high abuse potential.

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Dr. Keith Humphreys mentioned ✓ High confidence
"It is FDA approved for treatment resistant depression. There are some positive trials and I know a couple people who said it was very valuable to them in a deep depression but I didn't view it as quite the knockout I thought it was going to be."

Attribution: Balanced discussion of benefits and risks