David Sinclair

"The three main ones that we've been taking for over 15 years. Resveratrol in red wine. That's still a staple for us and we've got some really good data that we're going to submit to Nature on that. That's mixed with some olive oil or some yogurt so it dissolves."

"Resveratrol is a staple of mine for 15 years. I take about a gram of resveratrol. Look for white or slightly gray. If it's brown or brownish, throw it away. You can increase absorption five-fold by mixing it with either olive oil or a bit of yogurt."

"I take resveratrol... I take polyphenols from red wine and from vegetables either in a pill or in my food as a substitute."

"I do and I've been taking that since about 2004. But like I said, you can't just put it in water and drink it... I typically have some yogurt, a couple of spoonfuls, not a lot because I'm trying to fast until dinner, but I could mix it with olive oil."

"Realistically, you can only get the thousand milligrams that I take a day from a supplement that's pure. Now there are a lot of people selling resveratrol. If it's not light gray or white in color, throw it away... I put a couple of teaspoons of olive oil in a glass, mix around the resveratrol."

"The best example of that is resveratrol, which many people including myself take as a supplement. Grapes or grape vines produce that in abundance when they're dried out or they have too much light or fungus, and that we've shown activates the SIRT1 enzyme in our bodies."

"I still take it and we still study it in my lab... the way it really works, we know this is a fact from my lab, is that it's stimulating the body's defenses against aging and disease, because it's binding to these enzymes that we work on called sirtuins."

"I also take that with NMN, which is an NAD supplement. It's a precursor. We studied both in my lab and we just resubmitted a paper that showed that NMN is very good for the health of old mice and can extend the lifespan of mice, particularly females."

"One of the supplements that I take, which everyone knows about, NMN, could allow animals to grow new blood vessels by getting rid of a protein that accumulates with aging. We could mimic this lack of blood vessels with this pill. My father has been taking NMN, resveratrol, metformin, exercising."

"What I've started taking with my father is NMN and I take a gram of that as capsules every day. You just want to make sure it's really pure. It should either taste slightly sour like a sour patch kit if you're in the US, or there's a form of it that tastes a bit like sweet popcorn."

"I've been taking NMN and admitting that publicly for a while now and my father who is an even more advanced experiment at 86. So yes, we've been taking it for over a decade now and we're still alive"

"I take a precursor to NAD called NMN and the body uses that to make the NAD molecule in one step... if you take it for about two weeks, you'll double on average your NAD levels in the blood... we take a gram of NMN every day."

"One of the effects in mice at least of NMN, which is what we're taking, is improved blood flow. You get the benefits of exercise without having to exercise, if you're a mouse."

"Metformin requires a prescription. That's a type two diabetes drug. Relatively safe as a medicine. We take a gram a day of that."

"If I take metformin or the natural equivalent which is berberine... Taking it every other day, I think is better."

"I had terrible blood biochemistry. I was eating badly, I gained weight. I wasn't sleeping. I was stressed... So I went on NMN and things were somewhat rectified. And then I added Metformin and they really got back to my optimal."

"So I take Metformin... I always take Metformin in the morning, along with the resveratrol... But here's the thing, if I'm going to exercise that day, I will skip the Metformin."

"There's one called metformin, which is the diabetes drug, which I take. That in combination with these lifestyle changes should get us beyond a hundred."

"I can see on my monitor — the CGM — the great impact it's having on my body. I can monitor it on my rings. I do blood tests, which is important. You don't want to just guess what's working, what isn't."

"This one — I have a monitor on right now so I can see what's going on. I put one of these on my son and he stopped eating bad food for a long while. It was amazing what happened when he could see the crap that was going in his mouth was doing to his blood sugar. I think it's a great learning tool if nothing else."

"No, no, I used to, I learned a lot... They're very informative because you learn what your body reacts to and grapes were really bad."

"I've actually been on a statin to lower my LDL since I was 30... I insisted with my doctor initially with statins."

"I haven't noticed, and I've high cholesterol and I think it's worth it. But yeah, if there's nothing else wrong with you, you wouldn't take them."

"I swallow about 10,000 units of this stuff every morning. It's just a capsule. And I'm going to measure it. I typically do an ultrasound on my carotid every year and I'm going to see if nattokinase makes a difference."

"We recently added a couple of things to my father's regimen. One is nattokinase, which is an enzyme that comes from fermented soybeans. I have cardiovascular disease in my family."

"I'm also measuring it, a ring that matches my pulse and my sleep. — Is that the Oura? — Yeah."

"The reason that I take it is that it extends the lifespan of every animal that it's been given to from worms to mice. And it's a very safe molecule."