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Doxycycline

product
Last discussed Apr 16, 2026

An antibiotic that in this context is being used as a molecular switch to control the production of Yamanaka factors in gene therapy.

What creators say

David Sinclair
mentioned
Used for: Gene induction for age reversal therapy - 6 weeks of treatment to turn on OSK genes Praised: Well-established as gene inducer, most reliable system for their engineered a... vs: Chosen because well-established, ideally want to replace with non-antibiotic ...

"We used a molecule doxycycline. It's used to treat Lyme disease, but we're using it over a matter of a few weeks or really six weeks to turn on those three genes OSK. So really the deaging comes down to one shot and then antibiotic treatment for a..."

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+3 more mentions from David

"We give them doxycycline. It's used for malaria. It's used for Lyme disease. And we're using it in this case to turn these genes on."

"The genes go into the retina and we can turn it on with a drug called doxycycline. And we do that in the mice for four to eight weeks, then the eye..."

DS
David Sacks
mentioned

"the production of these Yamanaka factors can be turned on and off by taking an antibiotic called doxycycline"

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