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Apigenin

product

1 creator use or recommend it

1 use + recommend
Last discussed Sep 3, 2026

Chamomile extract supplement with calming effects

How Apigenin compares

1 creator weighed in
M
Magnesium Different focus
essential mineral supplement

Andrew pairs both for sleep, but apigenin specifically lowers anxiety to help turn off thinking beforehand.

1 creator
Andrew Huberman

"you know, something with magnesium, saffron, some apigenin, which is chamomile extract. And that would be the supplement version."

Combined with magnesium and saffron

Andrew Huberman

"The other supplement is apigenin, which is a derivative of chamomile... also acts as a bit of an anxiety-lowering compound, which is essential prior to sleep for people to essentially turn off their thinking."

Can be tested against or combined with magnesium threonate

P
Pinealon Direct rival
sleep peptide supplement

Andrew says try Apigenin first; Pinealon is a last resort after simpler options fail.

1 creator
Andrew Huberman

"I've gotten great benefit from the mag 3-and-8, apigenin, theanine stack. I don't think you need Pinealon until you've tried everything else, and then maybe try a supplement stack or even just one of those things."

Recommended before resorting to Pinealon

E
female hormone replacement therapy

Andrew warns apigenin can inhibit estrogen, so women considering both should be cautious.

1 creator
Andrew Huberman

"There's another supplement that could be quite useful, which is apigenin, which is a derivative of chamomile. 50 milligrams of apigenin also can augment or support this kind of creation of a sleepiness to help fall asleep and stay asleep."

Warns that it is a fairly potent estrogen inhibitor

What creators say

Andrew Huberman
uses recommends mentioned
Used for: Sleep improvement as part of a foundational supplement stack Praised: Part of a stack that provides great sleep benefit vs: Recommended before resorting to Pinealon

"I've gotten great benefit from the mag 3-and-8, apigenin, theanine stack. I don't think you need Pinealon until you've tried everything else, and then maybe try a supplement stack or even just one of those things."

More from Andrew Huberman →
+5 more mentions from Andrew

"I talk about ways to improve sleep — everything from tart cherry to apigenin to Suvorexant, which is one of the orexin drugs."

"you know, something with magnesium, saffron, some apigenin, which is chamomile extract. And that would be the supplement version."

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