Episodes featuring Greg Isenberg
Browse episodes where Greg Isenberg appears as host or guest. View all episodes →
Greg Isenberg lays out the kinds of businesses he thinks AI can't easily copy, from physical and licensed work to media, paid communities, marketplaces and unique data.
Greg Isenberg and Nick Vasilescu of Orgo walk through building a niche Grockbot-style agent platform for businesses, how Nick built his in a weekend, and how to sell it for $25,000 upfront plus a retainer.
Greg Isenberg argues that classic per-seat SaaS is dead because AI makes building software easy, and lays out a new model: give the tool away free, then charge for AI agents and human services.
Greg Isenberg talks with Jon Noronha, co-founder and chief product officer of Gamma, about agent harnesses: how Gamma built one, how it tests models, and where vertical harness startup opportunities remain.
James Dickerson, owner of a mobile diesel repair business, joins Greg Isenberg to explain how to sell AI-built marketing funnels to $2 to $20 million main street businesses instead of selling AI agents to tech insiders.
Greg Isenberg explains the "war on agents," as Amazon, Delta and Yelp block or charge AI shopping agents. He lays out nine stages he expects and what businesses and founders should do now.
Greg Isenberg argues that Meta Muse, a personal AI agent, opens an early arbitrage opportunity. He says it can mine Facebook groups, Marketplace and Instagram to match buyers and sellers, and could create 1,000-plus...
Greg Isenberg walks through three concrete ways to build profitable businesses using Gemini 4 Argon, covering interactive websites, personalized content, and custom physical products.
Greg Isenberg walks through eight GitHub repos builders can use to make money, speed up workflows, and find real customer problems worth solving.
Greg Isenberg outlines 13 business categories built to last in an AI-driven world, from AI-native service firms to physical assets, with paths that don't require big capital.
Greg Isenberg and Vas break down how forward-deployed engineers earn $1M+ a year by embedding AI agents inside enterprise workflows, with a concrete process for doing it.
Greg Isenberg breaks down OpenAI's DevDay 2026 announcements, focusing on the business opportunities builders can exploit through Dots, the Decisions API, Agents API, and Sign in with ChatGPT.
Greg Isenberg lays out how solo founders can acquire retiring small business owners' firms, deploy AI agents to cut costs, and scale margins from under 10% to 30-40%.
Greg Isenberg makes the case that Meta's Muse AI connectors are a major distribution opportunity for startups, similar to the 2008 App Store launch.
Greg Isenberg walks through how a solo operator can use AI tools to run a service business making $3,000 or more per day, with no employees.
Nicolas Cole, a writer who has made $30M online, joins Greg Isenberg to explain why AI content fails and how to build a writing style competitors cannot copy.
Greg Isenberg and Ryan Vogel introduce Jev, a new AI classifier model that makes fast, cheap decisions rather than generating text, and walk through practical ways founders can use it.
Greg Isenberg and Remy walk through Instinct AI, an invite-only personal agent app valued at $10 billion, covering what it does and whether it's worth using.
Ras Mic joins Greg Isenberg to explain how to build a software factory, a structured workflow using AI agents and markdown files to ship code at scale without conflicts or quality drops.
Greg Isenberg and Ras Mic walk through nine practical ways founders can use GPT-6 Astra to make money, from auditing apps to prototyping hardware.