Episodes featuring Greg Isenberg
Browse episodes where Greg Isenberg appears as host or guest. View all episodes →
Greg Isenberg and Nick Vasilescu of Orgo show how to run Grok 4.5 inside the Hermes agent as an AI co-founder. Nick argues its speed and low cost make it his main workhorse model.
Greg Isenberg and Jonathan Courtney rate hot takes from social media on AI, startups, and business strategy, sorting each as worth keeping or skipping.
Dan Shipper shows Greg Isenberg how he runs his work and life inside OpenAI's Codex with GPT 5.6, builds a demo app live, and argues SaaS still wins because people pay for maintenance.
Greg Isenberg makes the case that AI agents are a bigger opportunity than SaaS because they complete work rather than just assist with it, and shares a 7-step framework for building and selling agent-first businesses.
Greg Isenberg lays out six skills he believes grow more valuable as AI improves: managing agents, distribution, robotics, short-form curation, building and selling, and in-person community building. Each comes with a...
Greg Isenberg and Amir walk through how to set up GLM 5.2, Google's open-source AI model, in coding tools to cut token costs by around 5x.
Greg Isenberg talks with George Lampropoulos, a 19-year-old former TJ Maxx cashier who doesn't code, about how his AI-built app Wrestle AI made close to $200K, and his playbook for reaching $10K a month.
Greg Isenberg responds to Claude's sudden government ban by making the case for running AI models locally, and walks through how builders can set up a working local AI stack.
Greg Isenberg shares how to get more out of Claude Fable 5, covering specific prompts and workflows for founders and operators who want to build real things with it.
Ross Mike joins Greg Isenberg to explain what AI agent loops actually are and why most builders should skip them despite the hype.
Greg Isenberg talks with his co-founder Theo Taba about how to become an AI native person or company, where people manage agents, agents read and write company context, and the company gets smarter over time.
Alex Finn shows Greg Isenberg how to set up Hermes Agent Desktop, covering session management, model profiles, and automated agents that scan for business opportunities.
Greg Isenberg demos Codex Sites, OpenAI's no-code app builder that lets agents update and control your apps automatically without human intervention.
Greg Isenberg makes the case that AI agents are becoming major customers online, and walks through the infrastructure gaps and business opportunities this creates.
Greg Isenberg and Jonathan Courtney walk through nine startup opportunities in AI, health, community, and creator niches, focusing on underserved audiences with real money to spend.
Greg Isenberg talks with Nick Vasilescu of Orgo about running a one-person business that builds and manages AI agents for companies at $5,000 a month. They cover the offer, target markets, tools and setup.
Greg Isenberg walks through seven AI agent business ideas anyone can build today, focusing on small, low-risk opportunities that can generate $1,000–$3,000+ daily.
Meng To joins Greg Isenberg to show how Google's open-source Design.md format lets solo founders maintain consistent design across products using AI agents instead of a design team.
Andrew Wilkinson shows Greg Isenberg how AI agents run his startup, family office and daily life. He argues software is becoming a worse business, so he would rather buy TSMC and data center stocks.
Greg Isenberg and Imran Muthuvappa walk through installing and using Hermes Agent, a personal AI agent Imran says beats OpenClaw thanks to built-in memory, better stability and lower token costs.