← All episodes

Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray

| 14 products mentioned
Andrew Huberman Andrew Huberman host
Tony Wyss-Coray guest
Watch on YouTube aging reversal rejuvenation factors blood biomarkers young blood transfusion organ-specific aging exercise physiology growth factors

Huberman and Dr. Tony Wyss-Coray discuss groundbreaking research on rejuvenation factors in young blood that can reverse aging in the brain and other organs. The episode explores how blood-based proteins and growth factors change dramatically with age, and how transfusions or infusions of young plasma have shown promise in improving cognitive function and tissue repair in older individuals—while also examining the mechanisms behind exercise, fasting, and lifestyle interventions that activate these rejuvenating pathways.

Key takeaways
  • • Young blood contains rejuvenating factors including growth factors like GDF11 and proteins like clusterin that can reactivate stem cells, reduce inflammation, and improve memory in aged brains.
  • • Organ-specific aging clocks measured through blood protein analysis can predict which organs will age fastest and develop disease, allowing for personalized interventions before symptoms appear.
  • • Exercise, particularly high-intensity or explosive movement (sprinting, jumping), triggers the release of beneficial bloodborne factors like lactate-derived compounds that benefit brain and tissue health more than steady-state cardio alone.
  • • Caloric restriction and fasting activate multiple beneficial pathways including reduced inflammation, improved protein turnover, and mitochondrial health, though human clinical evidence for lifespan extension remains limited.
  • • While growth hormone and IGF-1 increase vitality and muscle maintenance, they also decrease lifespan—creating a trade-off between feeling youthful now versus living longer, requiring individual risk-benefit assessment.
  • • Therapeutic plasma exchange and young blood infusions show early promise in human trials for Alzheimer's and Parkinson's, but rigorous large-scale clinical trials are still needed before FDA approval.

Recommendations (4)

Airdyne Bike
Airdyne Bike uses

"I hop on the Airdyne bike, the one with the handles, and I'll go warm up a minute and I'll go hard for 20, 30 seconds, and then rest 10 seconds and just repeat. And it's over in like seven minutes."

Andrew Huberman · ▶ 1:31:28

Check price →
NMN uses

"I confess I take NMN powder. I don't have any belief that it's going to increase my lifespan, but it seems to have a pro energy effect that I like."

Andrew Huberman · ▶ 33:43

Check price →
Garmin
Garmin uses

"I measure my steps. I have a Garmin. I find it useful. I find also the sleep measurements really useful."

Tony Wyss-Coray · ▶ 1:45:17

Check price →
NAC (N-Acetylcysteine) uses

"Supplementing with NAC and acetylcysteine, both of which can support glutathione production and detoxification."

Andrew Huberman · ▶ 1:12:25

Check price →

Mentioned (10)

Spark "There's this idea that was at least to me first put forth in a book called Spark. Do you know Joh..." ▶ 51:25
Klotho "Klotho is actually another one. It's this protein that has been described to have beneficial effe..." ▶ 58:18
GDF11 "GDF11 is one of them that has been described. Growth and differentiation factor." ▶ 47:31
Lacylate "He found this interesting modified amino acid that is conjugated to lactate, lacylate it's called..." ▶ 1:27:44
Grifols "We worked collaborated very closely with a company called Grifols who is producing clinical medic..." ▶ 9:26
ChatGPT
ChatGPT "You can just ask ChatGPT. There's not in there what it says. And with NMN apparently and accordin..." ▶ 36:06
Clusterin "In our case, we described the protein that's called clusterin. It's involved in coagulation and c..." ▶ 49:20
GPLDH "Saul found another factor that's called GPLDH that again he can clearly show has an effect." ▶ 50:13
qigong "In a number of cultures they'll do qigong, tai chi which is deliberate breathing and movement and..." ▶ 1:41:24
tai chi "In a number of cultures they'll do qigong, tai chi which is deliberate breathing and movement and..." ▶ 1:41:24

More from these creators

Essentials: How to Build Strength, Muscle Size & Endurance | Dr. Andy Galpin

Andrew Huberman · Apr 02, 2026 · 6 recs

How Hormones Shape Sexual Orientation & Behavior | Dr. Marc Breedlove

Andrew Huberman · Mar 30, 2026 · 1 rec

Using Salt to Optimize Mental & Physical Performance | Huberman Lab Essentials

Andrew Huberman · Mar 26, 2026 · 1 rec

The Best Vitality & Health Protocols | Dr. Rhonda Patrick

Andrew Huberman · Mar 23, 2026 · 29 recs

Essentials: Tools for Setting & Achieving Goals | Dr. Emily Balcetis

Andrew Huberman · Mar 19, 2026 · 2 recs

Science-Based Meditation Tools to Improve Your Brain & Health | Dr. Richard Davidson

Andrew Huberman · Mar 16, 2026 · 1 rec