Retatrutide
1 creator use or recommend it
▲ 1 active in the last 90 days
A next-generation GLP-1 drug by Eli Lilly that can help people lose up to a third of their body weight with muscle sparing.
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How Retatrutide compares
4 creators weighed in
G
GLP-1
Direct rival
weight loss drug class
Joe says standard GLP-1 drugs cause muscle and bone loss, while retatrutide lets you keep muscle mass.
3 creators
3 creators
Joe says standard GLP-1 drugs cause muscle and bone loss, while retatrutide lets you keep muscle mass.
"Huberman says he thinks retatrutide will be a trillion-dollar drug. What do you reckon about that?"
Discussed in the context of next-generation GLP-1 class drugs
"There's the retatrutide stuff. That one is a weird one because that one allows you to keep muscle mass. And that's the big fear that people have — is that you're starving yourself, but you're also losing bone mass and muscle mass."
Compared to standard GLP-1 drugs which cause muscle and bone mass loss
"You probably know these as things like Ozempic, Mounjaro, and retatrutide"
Listed alongside Ozempic and Mounjaro as GLP-1 examples
Ozempic
Direct rival
semaglutide weight loss drug
Joe says Retatrutide gives fat loss without muscle or bone loss that Ozempic causes. It also hits more body systems, making it the most effective GLP so far.
2 creators
2 creators
Joe says Retatrutide gives fat loss without muscle or bone loss that Ozempic causes. It also hits more body systems, making it the most effective GLP so far.
"Lilly developed retatrutide, which hits the GLP, GIP, and glucagon system, leads to the most robust weight loss, seems to spare some muscle, perhaps. People should always resistance train anyway to offset that, but it's the most effectiv..."
Compared to Ozempic and Mounjaro; hits GLP, GIP, and glucagon systems vs. fewer targets
"This one they think is going to be incredible because this one is going to give you all the fat loss but none of the muscle loss, none of the bone density loss."
Compared to Ozempic which causes muscle and bone loss
T
Tirzepatide
Direct rival
approved GLP-1 weight loss drug
Retatrutide is not yet FDA approved, while Tirzepatide (Mounjaro) is already prescribed.
C
1 creator
C
1 creator
Retatrutide is not yet FDA approved, while Tirzepatide (Mounjaro) is already prescribed.
"Right now I'm taking 10 milligrams of retatrutide every 5 days. Phase 2 clinical trials have really shown that even at high doses, retatrutide as high as 12 milligrams has proven to be safe. Retatrutide is also good for non-fatty acid li..."
Compared to other GLP-1s; noted that Retatrutide is not yet FDA approved but Mounjaro (tirzepatide) is currently prescribed
What creators say
"Right now I'm taking 10 milligrams of retatrutide every 5 days. Phase 2 clinical trials have really shown that even at high doses, retatrutide as high as 12 milligrams has proven to be safe. Retatrutide is also good for non-fatty acid liver."
More from Clavicular →
"There are people out there that think they're buying retatrutide. Yeah, no, they're not. Maybe use the GMP process as a way to explain why when you think you're buying retatrutide peptide for research purposes only, you are definitely not buying w..."
More from Peter Attia →+1 more mention from Peter
"Take retatrutide as an example. Retatrutide is not just the amino acid sequence. Anyone trying to turn that sequence into a reproducible pharmaceut..."
"Huberman says he thinks retatrutide will be a trillion-dollar drug. What do you reckon about that?"
More from Chris Williamson →
"There's the retatrutide stuff. That one is a weird one because that one allows you to keep muscle mass. And that's the big fear that people have — is that you're starving yourself, but you're also losing bone mass and muscle mass."
More from Joe Rogan →+1 more mention from Joe
"This one they think is going to be incredible because this one is going to give you all the fat loss but none of the muscle loss, none of the bone ..."
"Lilly developed retatrutide, which hits the GLP, GIP, and glucagon system, leads to the most robust weight loss, seems to spare some muscle, perhaps. People should always resistance train anyway to offset that, but it's the most effective of those..."
More from Andrew Huberman →+2 more mentions from Andrew
"You probably know these as things like Ozempic, Mounjaro, and retatrutide"
"Retatrutide went through phase three at Lily people can lose up to a third of their body weight in a pretty short amount of time with some degree o..."
"We have now done studies including with our most powerful medicine which we hope to launch next year the triple acting retatriotide that basically demonstrated that for knee pain a common form of arthritis it was the most powerful pain reducing ag..."
More from David Sacks →"We're talking losing 20 to 25% of total body weight within a relatively short period of time. I think this is going to be a trillion dollar drug when it comes out"
More from Alex Tatem →"Retatrutide is a triple agonist being developed by Eli Lilly. It hits three different receptor sites. It has less muscle wasting, much better safety profile, lower side effect profile, but people drop substantial amounts of body fat."
More from Brigham Buhler →
"and then there is Retatrutide which is the popular one in San Francisco that is the third gen peptide for a bunch of things but weight loss is the one that people know"
More from TBPN →
"We initially thought GLP-1's like Ozempic, Zepbound, and retatrutide just reduced food cravings. Now we know they work for alcohol and gambling and other addictions, too."
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