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Methylone

product

1 creator use or recommend it

▲ 1 active in the last 90 days

1 use 2 mention
Last discussed Oct 3, 2026

A psychoactive empathogenic compound described as a shorter-acting, lower-body-load cousin of MDMA, being commercialized by Transcend Therapeutics for therapeutic use.

How Methylone compares

3 creators weighed in
M
MDMA Direct rival
classic therapeutic empathogen drug

Methylone is shorter (45-60 min vs 4-6 hrs) and gentler, with less body load and less serotonin depletion, making weekly dosing possible.

K
3 creators
Tim Ferriss

"I had my first methylone experience probably 2015... an incredibly beautiful gentle experience, and maybe the soft-spoken, shorter-staying cousin of MDMA. So rather than coming in and you're like, when's this guy gonna leave, six hours, ..."

Softer and shorter-acting than MDMA

KR
Kevin Ryan

"What most people didn't realize at the time is that it has some advantages over MDMA... You can take methylone once a week in our trials. You actually can't take MDMA once a week. It's a little bit more toxic. It depletes your serotonin ..."

Compared to MDMA

Tim Ferriss

"Methylone is, for lack of a better descriptor, it's like the softer, gentler cousin of MDMA who just comes in for a quick hello as opposed to sitting down for dinner. It's like a 45 to 60 minute hello as opposed to 4 to 6 hours."

Compared to MDMA as a shorter, gentler alternative

Andrew Huberman

"Methylone is a very, very interesting compound. It's like the shorter acting, softer cousin of MDMA — much less body load. Very, very interesting compound. They did, which was very smart, they just completely separated the two and actual..."

Compared to MDMA as a softer, shorter-acting alternative

What creators say

Tim Ferriss
uses mentioned
Praised: Gentle, beautiful experience with a shorter duration vs: Softer and shorter-acting than MDMA

"I had my first methylone experience probably 2015... an incredibly beautiful gentle experience, and maybe the soft-spoken, shorter-staying cousin of MDMA. So rather than coming in and you're like, when's this guy gonna leave, six hours, it's more ..."

More from Tim Ferriss →
+1 more mention from Tim

"Methylone is, for lack of a better descriptor, it's like the softer, gentler cousin of MDMA who just comes in for a quick hello as opposed to sitti..."

KR
Kevin Ryan
mentioned
Used for: Treatment of PTSD, with patents for depression and anxiety Praised: Can be taken weekly, less toxic, less serotonin depletion, fewer comedowns, s... vs: Compared to MDMA

"What most people didn't realize at the time is that it has some advantages over MDMA... You can take methylone once a week in our trials. You actually can't take MDMA once a week. It's a little bit more toxic. It depletes your serotonin a little b..."

More from Kevin Ryan →
Andrew Huberman
mentioned
Used for: Therapeutic empathogenic treatment without requiring combined psychotherapy Praised: Shorter acting, less body load than MDMA, good clinical outcomes without psyc... vs: Compared to MDMA as a softer, shorter-acting alternative

"Methylone is a very, very interesting compound. It's like the shorter acting, softer cousin of MDMA — much less body load. Very, very interesting compound. They did, which was very smart, they just completely separated the two and actually removed..."

More from Andrew Huberman →

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