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Semaglutide

Semaglutide

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Last discussed Oct 12, 2026

A GLP-1 medication used for weight loss and diabetes management.

How Semaglutide compares

2 creators weighed in
T
Tirzepatide Direct rival
dual-action weight loss drug

Both treat obesity, but Tyna says some people get no results from semaglutide and switch to tirzepatide with life-changing results.

L T
2 creators
LB
Lloyd B. Klickstein

"Everything changed when Novo's data came out with semaglutide, which was amazing. It was the first really effective obesity medical therapeutic."

Combined with Bagramab in the BELIEVE study; compared to tirzepatide and liraglutide in mouse studies

TM
Tyna Moore

"Semaglutide — that's just pure GLP-1. That would be Ozempic and Wegovy. And some people don't respond at all to semaglutide and tirzepatide helps them. It changes their life like night and day."

Compared to tirzepatide; some patients respond better to tirzepatide than semaglutide

What creators say

SK
Scott Kanoski
mentioned

"I'm not deeply familiar with them, but I believe that semaglutide may be FDA approved in some populations of teenagers, but I don't remember the specific parameters for that."

More from Scott Kanoski →
LB
Used for: Combination therapy with Bagramab for obesity and sarcopenic obesity Praised: First really effective obesity medical therapeutic; additive efficacy with Ba... vs: Combined with Bagramab in the BELIEVE study; compared to tirzepatide and lira...

"Everything changed when Novo's data came out with semaglutide, which was amazing. It was the first really effective obesity medical therapeutic."

More from Lloyd B. Klickstein →
AK
Alok Kanojia
mentioned
Used for: Weight loss, reducing cravings, treating type 2 diabetes and cardiac risk factors Praised: Effective for morbidly obese patients, reduces alcohol cravings, cardiac and ... vs: Compared to older fat-blocking medications with unacceptable side effects (an...

"What scares me about semaglutide is up until now, if you wanted to lose weight, if you wanted to get fit, it required you to put in a certain amount of effort. They're amazing medicines because if you have like if you're overweight and you have ca..."

More from Alok Kanojia →
TM
Tyna Moore
mentioned
vs: Compared to tirzepatide; some patients respond better to tirzepatide than sem...

"Semaglutide — that's just pure GLP-1. That would be Ozempic and Wegovy. And some people don't respond at all to semaglutide and tirzepatide helps them. It changes their life like night and day."

More from Tyna Moore →
Peter Attia
mentioned
Used for: Cited as an example of a drug with proven efficacy in RCTs, illustrating the value of controlled trials Praised: Produced significantly more weight loss than placebo in the STEP 1 study

"In the STEP 1 study, semaglutide produced far more weight loss than placebo, so the drug effect was real."

More from Peter Attia →
SH
Steve Horvath
mentioned
Used for: Significant weight loss in obese individuals Praised: Causes substantial weight loss that affects all aging clocks vs: More effective than caloric restriction alone

"These people really lost a lot of weight over 33 weeks with semaglutide treatment and suddenly all methylation clocks picked it up."

More from Steve Horvath →
CS
Cameron Sapa
mentioned

"with these prescription GLP1s semaglutide tirzepatide there it's clinical studies are showing 14.7% weight loss 22% weight loss"

More from Cameron Sapa →

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