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Thiazide diuretics
Last discussed Sep 7, 2026
A class of diuretic medications commonly used to treat high blood pressure by promoting sodium and water excretion by the kidneys.
Recently discussed in
Blood pressure: how to measure, manage, and treat high blood pressure (AMA #48 rebroadcast)
Peter Attia · Sep 7, 2026
What creators say
Peter Attia
mentioned
Used for: Add-on blood pressure treatment when ACE inhibitors or ARBs are insufficient
Praised: Highly efficacious (~15 mmHg systolic reduction)
vs: More side effects than ACE inhibitors/ARBs; reserved as add-on rather than fi...
"Thiazide diuretics and calcium channel blockers are also highly efficacious. Those are easily in the 15 mm of mercury and 9 to 10 millimeters of mercury impact on blood pressure, but they do tend to come with more side effects. We typically do not..."
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