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MDMA-Psilocybin combination
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▲ 1 active in the last 90 days
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Last discussed Aug 1, 2026
A clinical protocol combining MDMA (an empathogen) taken first, followed by a high dose of psilocybin a couple of hours later, used for deep psychological work.
Recently discussed in
Why Dr. Andrew Huberman Changed His Mind About Psychedelics
Andrew Huberman · Aug 1, 2026
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Andrew Huberman
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Used for: Deepest psychological rewiring work; accessing and processing the hardest emotional material that neither compound alone nor standard therapy could reach
Praised: Eliminated the MDMA two-day drop; provided self-compassion (empathogenic effe...
vs: Compared to MDMA alone (which has a two-day drop), psilocybin alone (which wa...
"The hardest work I've ever done was to take MDMA and then a couple hours later take a high dose of psilocybin. No two-days-later drop, which you do experience with MDMA — I just did not experience that if I took psilocybin with it. Remarkable. Had..."
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