Episodes featuring Dave McClure

Browse episodes where Dave McClure appears as host or guest. View all episodes →

This Week in Startups
VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341
This Week in Startups · with Dave McClure, Jeff Clavier, Jenny Fielding · Sep 23, 2026 · 6 recommendations

Three veteran VCs debate whether open-source or frontier AI models are better bets, and why today's seed valuations make traditional venture returns nearly impossible.

This Week in Startups
Is There Anything Left to Fund Besides AI? | EP 2330
This Week in Startups · with Sheel Mohnot, Dave McClure, Hussein Kanji · Aug 27, 2026 · 2 recommendations

Jason Calacanis and three venture capitalists debate what is worth funding in 2026, covering AI job displacement, secondary markets, robotics, and child safety regulation.

This Week in Startups
Bill Gates foresees massive AI job loss: these VCs disagree | E2330
This Week in Startups · with Sheel Mohnot, Dave McClure, Hussein Kanji · Aug 26, 2026 · 3 recommendations

Three VCs debate Bill Gates' warning about AI job losses, weighing evidence of job creation, productivity gains, and emerging opportunities in robotics and agent-based software.

This Week in Startups
How Many Startups Will Survive OpenAI? | E2288
This Week in Startups · with Jenny Fielding, Dave McClure, Sam Lessin · May 14, 2026 · 1 recommendation

Jenny Fielding, Dave McClure, and Sam Lessin join This Week in Startups to discuss how frontier AI companies like OpenAI and Anthropic are threatening venture-backed startups and reshaping VC.