VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341

This Week in Startups · · 1 hr 26 min

Three veteran VCs debate whether open-source or frontier AI models are better bets, and why today's seed valuations make traditional venture returns nearly impossible.

Watch the episode 1 hr 26 min · YouTube

The gist

  1. Open-source models already handle 78% of token usage, leading most VCs to avoid funding startups built on closed models.
  2. Seed valuations jumped from a median of $8M in 2017 to $28M in 2026, making the math on fund returns much harder.

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Also mentioned

18:05 Claude · "The example you cite is because Claude is monitoring the usage of their products now."
21:25 Stripe · "Stripe is not a payments company. Stripe is an anti-fraud company. And so if you think about fraud..."
23:30 Instinct · "Instinct is an AI assistant that works through your iMessage. They seeded it with the VC community and..."
24:13 Harmonic · "They now have 100,000 users according to Harmonic, our partner here. Instinct went from founding to a $2.5..."
31:26 Cursor · "Cursor had two or three billion and they got valued at 60. This has zero and is at 10."
43:17 ChatGPT · "OpenAI's GPT-6 Soul and Luna came in about 50% cheaper with Soul at $2 per million tokens."

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