VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341
Three veteran VCs debate whether open-source or frontier AI models are better bets, and why today's seed valuations make traditional venture returns nearly impossible.
The gist
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Open-source models already handle 78% of token usage, leading most VCs to avoid funding startups built on closed models.
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Seed valuations jumped from a median of $8M in 2017 to $28M in 2026, making the math on fund returns much harder.
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A $300M fund needs $150M per exit, so a $24M seed post-money demands 30x growth, effectively requiring a decacorn outcome.
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If a good investor offers clean terms at a fair valuation, the panel says founders should take it immediately rather than wait.
"I would like to thank Gemini for making me graphics that I would have paid an illustrator $300 for and waited six weeks. I just made that while you were talking, Jenny."
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See all on the Lovable pageWhat they recommend · 6 picks
"This is really about how to donate illiquid assets — stock in a startup company, GP or LP interest in a fund, even carried interest in a fund. Instead of donating your cash, you..."
"I would like to thank Gemini for making me graphics that I would have paid an illustrator $300 for and waited six weeks. I just made that while you were talking, Jenny."
"Not all donor advised funds accept these assets, but UI Charitable, which we work with out of Utah, does."
This Week in Startups
4 picks · host
"I would like to thank Gemini for making me graphics that I would have paid an illustrator $300 for and waited six weeks. I just made that while you were talking, Jenny."
"Check out TaxGPT if you're an accountant. They've now hit tens of millions of dollars in revenue, thousands of tax and accounting firms using it, and it is a fantastic startup t..."
"I use Perplexity as well."
Dave McClure
2 picks · guest
"This is really about how to donate illiquid assets — stock in a startup company, GP or LP interest in a fund, even carried interest in a fund. Instead of donating your cash, you..."
"Not all donor advised funds accept these assets, but UI Charitable, which we work with out of Utah, does."
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