Episodes featuring a16z
Browse episodes where a16z appears as host or guest. View all episodes →
PayPal and Affirm co-founders Alex Rampell and Max Levchin talk about why the credit card has resisted disruption for decades and whether AI agents can finally change payments.
Moderna CEO Stéphane Bancel talks with a16z about the company's personalized mRNA cancer vaccine, which showed positive Phase 3 results in melanoma after decades of failed attempts.
Mathematician Daniel Litt joins a16z to discuss what advanced AI models can and cannot do in math, and what that means for the future of the field.
a16z investors Gavin Baker and David George make the case that AI compute demand will outrun supply through 2028, creating an unusual investment window rather than a bubble.
a16z partners Ben Horowitz, Martin Casado, and Raghu Raghuram discuss their new Machine Age Fund and why AI's biggest bottleneck has shifted from software to physical infrastructure like chips, power, and data centers.
a16z investors break down how Cursor grew so fast by focusing on the human-AI interface rather than building foundational models, and how tight product focus beat giants like Microsoft Copilot.
a16z partner Anish Acharya breaks down where AI value is actually being captured, arguing the application layer beats model competition and consumer AI is finally viable.
Steven Sinofsky and Martin Casado discuss how AI has flipped startup economics, shifting the bottleneck from engineering talent to capital.
a16z partners Angela Strange and Gabriel Vasquez explain "borderless founders," international builders with global ambitions, and why diaspora networks, local talent and home-market customers can give them an edge...
Grant Lafontaine, co-founder of Whatnot, joins a16z to discuss how live shopping is growing in the US and what makes the platform work for sellers and buyers.
Will Gaybrick of Stripe talks with a16z about how AI is changing how software gets built, how Stripe is growing faster, and how agents will reshape payments.
Travis Kalanick joins a16z to discuss his new company Adam, which aims to automate physical-world industries like food production, mining, and logistics using AI, robotics, and sensors.
On the a16z podcast, Joe Schmidt and Andy McCall explain two sales playbooks for AI startups: lighthouse, winning famous logos for proof, and land grab, selling to any buyer who already has budget for the math.
Garry Tan, president of Y Combinator, talks with a16z about how AI agents are changing what small founding teams can build and how founders should think about growth, hiring, and defensibility.
Alejandro Maza Ayala, head of AI at Kavak, tells a16z how the Latin American used car company rebuilt itself around AI agents, from per-customer sales agents to an AI CEO pilot, and why shallow AI adoption fails.
Dylan Ayrey and Feross Aboukhadijeh talk about how AI is being trained to hack systems autonomously, exploiting weak credentials and software supply chains faster than humans can patch.
Simon Mo and Matt Bornstein discuss how open-source AI infrastructure, led by tools like vLLM, has become the foundation of modern AI deployment across major cloud and API services.
Turner Caldwell, CEO of Mariana Minerals, talks about why the US lost control of critical mineral production to China and how software-driven automation can bring domestic mining back.
Tori Shivanandan and Doug Bernauer of Radiant join a16z to explain how factory-built micro reactors could make nuclear power as simple to deploy as a diesel generator.
Jesse Zhang and Ashwin Sreenivas of Decagon explain how to build enterprise AI applications that scale, covering model selection, task decomposition, and selling AI to large companies.