Mark Cuban on Why AI Could Turn Solo Founders Into Trillionaires

a16z · · 1 hr 0 min

Mark Cuban joins a16z to explain how Cost Plus Drugs and direct contracts aim to fix broken healthcare economics, and why he believes AI makes now the best time ever to be an entrepreneur.

Watch the episode 1 hr 0 min · YouTube

The gist

  1. Cuban urges employers to run benefits contracts through AI to find where they are being ripped off, and he uses agents on several plans, including Gemini.
  2. Cuban had ChatGPT design a cheaper, GLP-1 friendly rival to a food executive's top cookie, with a full bill of materials, in about 3 minutes.

What they recommend · 3 picks

"I'm running my existing contract through AI and I'm using a prompt that asks a single question. Where are they [ __ ] me over? What should I do about it? And within 30 seconds, ..."

ChatGPT AI tools

"Let's take your number one product, your cookie, right? And I'm going to ask ChatGPT to create a competitor that is more GLP-1 friendly and will be priced lower. And I want a fu..."

Mark Cuban ·159 creators recommend it·Mark's AI tools →
Gemini AI tools

"And then I have the Gemini plan. And then I have OpenAI's plan, etc. etc. And I use the agents and I say you go out and find me every state entity organization enterprise that h..."

Mark Cuban ·73 creators recommend it·Mark's AI tools →

Made by someone on this episode

Team Cuban Card · Mark Cuban's — A discount card for picking up Cost Plus Drugs medications at affil...
Cost Plus Marketplace · Mark Cuban's — A marketplace selling sterile injectables and other drugs to hospit...
agentfeeds.dev · Mark Cuban's — An experimental tool that converts social posts and transcripts int...

Also mentioned

7:02 STAT News · "The thing I'm most proud of, and actually STAT News just wrote a story on this yesterday, the day before,..."
9:40 Cost Plus Wellness · "I want the ability to take the contract we signed, this direct contract between us, and publish it on..."
20:16 Google Drive · "And so I put it up on Google Drive and each of the different LLMs has access to it. And I just tell them..."
38:59 23andMe · "How expensive is 23andMe? You pay $99 or less now to get your DNA looked at."
41:29 Open Evidence · "They won't be taught the exact same things. They'll have to learn how to use OpenEvidence or whatever else..."
46:19 Epic · "The EHR is dominated by Epic and it's their world, you know, and so I've just kind of deferred to them and..."

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