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Valproic Acid
Last discussed Aug 31, 2026
An anti-seizure medication (brand name Depakote) FDA approved for migraine prevention, working partly via GABA pathways.
Recently discussed in
406 ‒ Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment
Brian Grosberg · Aug 31, 2026
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BG
Brian Grosberg
mentioned
Used for: Preventive treatment for migraine
Praised: Works via GABA pathway; can be helpful
vs: Mentioned alongside topiramate as FDA-approved anti-seizure drugs for migrain...
"Valproic acid, or Depakote, can have effects on GABA as well. That medication may be helpful but also has potential side effects. It's really important to consider the patient population — the vast majority of people with migraine are women — so r..."
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