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Tamoxifen

product
Last discussed Oct 14, 2026

A chemotherapy drug that was repurposed in Sinclair's research to activate a gene from slime mold that breaks DNA in mice.

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Thaïs Aliabadi
mentioned
Used for: Breast cancer risk reduction in high-risk women Praised: Reduces breast cancer risk by about 50% vs: Cannot be combined with hormone replacement; alternative to risk-reducing mas...

"One option is to put these patients on tamoxifen, hormone blockers. If they take tamoxifen every day for five years, then you can reduce their risk by like fifty percent for the following ten years. But that throws them into menopause."

Why Younger Women Are Getting Breast Cancer at Record Rat... · ▶ 56:05 · Oct 14, 2026
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David Sinclair
mentioned

"We could feed it a drug tamoxifen which is used in chemotherapy. And that drug turned on a gene from a slime mold"

Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, ... · ▶ 31:32 · Mar 23, 2026
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