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Robin Carhart-Harris REBUS Model
Last discussed Aug 17, 2026
The Relaxed Beliefs Under Psychedelics (REBUS) model proposed by neuroscientist Robin Carhart-Harris, describing how psychedelics work by relaxing overly rigid prior beliefs in the brain to enable neuroplasticity and therapeutic change.
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404 ‒ Mental health beyond neurotransmitters: hormones in psychiatry, psychedelic therapies, & more
Linus Abrams · Aug 17, 2026
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Linus Abrams
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Used for: Theoretical framework for understanding how psychedelics produce neuroplasticity and therapeutic change in depression and anxiety
Praised: Explains durable therapeutic effects through a neuroplasticity lens; connects...
"The Robin Carhart-Harris REBUS model — Relaxed Beliefs Under Psychedelics — is about neuroplasticity for adjusting maladaptive priors. People who have beliefs that are problematic for them, underpinning a lot of depressive and anxiety disorders. A..."
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