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Polygenic Risk Score
Last discussed Jul 1, 2026
A genomic tool that aggregates many genetic variants to estimate an individual's inherited risk for diseases like cardiovascular disease, enabling early identification of high-risk patients.
Recently discussed in
It's Not Cholesterol. Inflammation Is What's Actually Causing Heart Disease
Eric Topol · Jul 1, 2026
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ET
Eric Topol
mentioned
Used for: Early identification of genetic cardiovascular risk, 20+ years before heart disease manifests
Praised: Very inexpensive; captures inherited risk that standard lipid panels miss
vs: Part of a 'full stack' alongside lipid panel, Lp(a), heart clock, and inflamm...
"We can get a simple lipid panel, add LP(a), so a little more than what is the standard lipid panel — we can also get a polygenic risk score, very inexpensive, we can also get a heart clock, and we can get inflammation markers. Now you have the ful..."
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