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Clozapine
Last discussed Sep 17, 2026
An atypical antipsychotic medication used primarily for treatment-resistant schizophrenia, requiring regular blood monitoring due to risk of agranulocytosis.
Recently discussed in
Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & Jung | Lex Fridman Podcast #502
Andrew Scull · Sep 17, 2026
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Andrew Scull
mentioned
Used for: Treatment-resistant schizophrenia cases that don't respond to other antipsychotics
Praised: Tends to work better in treatment-resistant cases; less likely to cause tardi...
vs: Compared to first-generation antipsychotics; prompted development of second-g...
"Clozapine was developed by a small company... It tends to work better in treatment-resistant cases, meaning cases that don't respond to the other antipsychotics that we have. And it could be revived but at the cost of weekly blood checks."
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