Episodes featuring Y Combinator
Browse episodes where Y Combinator appears as host or guest. View all episodes →
Pete Koomen shares how Y Combinator built internal AI agent infrastructure, moving beyond AI as a writing tool to a shared organizational brain any startup can copy.
Eric Ries, author of The Lean Startup, joins Y Combinator to explain how founders can use legal structures to protect their company's mission from investor pressure and mission drift.
A Y Combinator partner explains how to redesign a company as a self-improving AI loop rather than using AI as a simple productivity tool.
Aadit Palicha explains how he turned down Stanford to build Zepto, India's 10-minute grocery delivery platform, and what drove that bet.
Paul Graham makes the case for why ambitious founders should spend time in Silicon Valley, and how that experience can help build stronger startup ecosystems back home.
Y Combinator's Garry Tan explains how he shipped hundreds of thousands of lines of code while running YC full-time by using AI agents as a force multiplier.
Harshil Mathur tells Y Combinator how Razorpay became India's largest payments company by serving startups and small businesses in a heavily regulated market.
Y Combinator's François Chéard explains how recursive inference in small AI models can outperform much larger LLMs on reasoning tasks, based on two key 2025 papers.
Demis Hassabis, CEO of Google DeepMind, talks with Y Combinator about what is missing from current AI systems and what the path to AGI looks like by around 2030.
Replit CEO Amjad Masad joins Y Combinator to discuss how AI-native tools let non-technical people build real software, and what jobs will survive in an AI-run company.
Diana from Y Combinator makes the case for building AI into the core of a startup from day one, covering team structure, workflows, and how to move faster than established companies.
Y Combinator's Gary Tan shows how to use Claude Code and the open-source GStack framework to run AI agents like a full engineering team, shipping work in weeks instead of months.
Katie Dill, Stripe's head of design, talks with Y Combinator about how Stripe redesigned their homepage, balancing visual craft with clarity across many products.
Quan Vuong of Physical Intelligence joins Y Combinator to explain why robotics is having its GPT moment and how founders can build vertical robotics businesses today.
Y Combinator profiles BillionToOne, a biotech company that detects rare genetic signals in blood to enable prenatal and cancer testing, growing from a $300K startup to a $4B+ valuation.
François Chollet, creator of Keras and founder of NDIA, joins Y Combinator to argue that scaling alone cannot achieve AGI and explains his symbolic program synthesis approach as an alternative.
Gaurab Chakrabarti and Sean Hunt of Solugen join Y Combinator to explain how they built a billion-dollar chemical startup using enzymes and metal catalysts instead of fossil fuels.
Mukund and Madhav Jha, founders of Emergent, talk about how their AI coding platform helped non-technical users build 7 million apps in 8 months.
Max Hodak, co-founder of Neuralink and founder of Science, talks with Y Combinator about brain-computer interfaces, his retinal prosthesis Prima, and the future of neural engineering.
Y Combinator partners review startup landing pages built with AI design tools, pointing out recurring mistakes that make sites look generic and hurt conversions.